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Blood Pathology Lab혈액병리 연구실

Danyeong Kim

박사과정

소개

Danyeong Kim은 알츠하이머병, 파킨슨병 및 관련 질환 환자에게서 발견된 유전자 돌연변이가 단백질 기능을 어떻게 바꾸는지 연구합니다. CRISPR/Cas9으로 APP Val604Met, PSEN1 Gly417Ala 돌연변이를 도입한 세포, TREM2 변이(T44A, L15Q)의 세포 모델과 아밀로이드-β에 미치는 영향, 파킨슨병 돌연변이 ATP10B R303W를 연구했습니다.

또한 TUG(Timed Up and Go) 검사를 이용한 파킨슨병 환자의 보행·균형 측정, 혈액 엑소좀의 아세틸콜린에스테라아제 활성 측정, 아밀로이드-β 올리고머 형성을 억제하는 화합물 연구를 수행했습니다.

연구 관심 분야

  • 돌연변이 기능 연구

연구 분야

제1저자 논문

논문 12편

연구실 구성원의 ORCID 기록에서 자동으로 갱신됩니다.

2026

  1. Danyeong Kim, Minji Son, Jeanhong Jeon, Da-Eun Jeong, Hyun Kyung Yi, Min Ju Kang

    Quantitative Analysis of Timed Up and Go Metrics Across Parkinson’s Disease Severity and Their Clinical Correlations

    Diagnostics 16(14):2283

    DOIPubMed

  2. Danyeong Kim, Heewon Bae, Kyu Hwan Shim, Hyewon Yang, Da-Eun Jeong, Min Ju Kang, Seong Soo A. An

    A novel TREM2 L15Q in signal peptide domain and its influence on Aβ pathogenicity

    npj Dementia 2(1)

    DOIPDF

2025

  1. Danyeong Kim, Da‐Eun Jeong, Yunseo Gong, Hongjae Ahn, Min Ju Kang, Seong Soo A. An

    Characterization of ATP10B R303W as a Novel Pathogenic Mutation in Parkinson's Disease

    Alzheimer s & Dementia 21(S1):e097660

    DOIPubMedPDF

  2. Danyeong Kim, KyuHwan Shim, Jinho Kim, Geon Ko, Mario A. Tan, Keun-A Chang, Seong Soo A. An

    Potential anti-amyloid beta oligomerization effects of PD166793 in Alzheimer's disease

    Experimental Neurology 396:115504

    DOIPubMed

  3. Danyeong Kim, Da-Eun Jeong, Hyunkyung Yi, Min Ju Kang

    Gait Patterns and Balance Impairment in Parkinson’s Disease With Correlation to Disease Severity

    Dementia and Neurocognitive Disorders 24(4):259

    DOIPubMedPDF

2024

  1. Danyeong Kim, Kyu Hwan Shim, Yunseo Gong, Hye-Won Yang, Min Ju Kang, Seong Soo A. An

    Examining pathology of Alzheimer’s disease via clusterin and Aβ interaction

    Alzheimer s & Dementia 20(S1):e087898

    DOIPubMedPDF

2023

  1. Danyeong Kim, Nayoung Ryoo, Young Ho Park, Eva Bagyinszky, Seong Soo A. An, SangYun Kim

    A Novel Mutation in Sacsin, p.Val1335IIe, May Cause Late-Onset Sacsinopathy Due to Haploinsufficiency

    Current Issues in Molecular Biology 45(12):9917–9925

    DOIPubMedPDF

  2. Danyeong Kim, Kyu Hwan Shim, Hye-Won Yang, Heewon Bae, Min Ju Kang, Seunghwan Shin, Jongsung Kim, Kyusik Yun, Chang‐Hyun Jang, Seong Soo A. An

    Pathogenic characteristics of genetically modified cells with TREM2 T44A mutation

    Alzheimer s & Dementia 19(S13)

    DOIPDF

2022

  1. Danyeong Kim, Kyu Hwan Shim, Eva Bagyinszky, Giau Van Vo, Min Ju Kang, Vorapun Senanarong, Chanin Limwongse, Seunghwan Shin, SoonPyo Jeong, Jongsung Kim, Young Ho Park, Young Chul Youn, SangYun Kim, Seong Soo A. An

    Characteristics of β‐secretase activity on APP‐V604M and APP‐V669L

    Alzheimer s & Dementia 18(S3)

    DOI

  2. Danyeong Kim, Kyu Hwan Shim, Eva Bagyinszky, Seong Soo A. An

    Prion Mutations in Republic of Republic of Korea, China, and Japan

    International Journal of Molecular Sciences 24(1):625

    DOIPubMedPDF

2021

  1. Danyeong Kim, Giau Van Vo, Eva Bagyinszky, Seong Soo A. An

    PSEN1 Gly417Ala by CRISPR/Cas9 in functional pathogenicity

    Alzheimer s & Dementia 17(S3)

    DOI

2020

  1. Danyeong Kim, KyuHwan Shim, Giau Van Vo, Eva Bagyinszky, Seong Soo A. An

    Functional characterizations of APP VAL604MET by CRISPR/CAS9

    Alzheimer s & Dementia 16(S2)

    DOIPDF