혈액 기반 바이오마커

주요 연구 방법

• 단백질 올리고머 검출을 위한 다중체 검출 시스템(MDS)
• 혈장 아밀로이드-β, TDP-43, α-시누클레인 측정
• 에피토프 매핑 면역분석
• 아밀로이드 PET 결과와의 비교

관련 연구 성과

1. Hojin Kang, Hongju Kim, Woo Jung Kim, Leon French, Hyunjung Oh, Seong Soo A. An

   Vitronectin Modulates Plasma Aβ Oligomerization Propensity Within Altered Albumin Interactome Networks in Alzheimer’s Disease

   International Journal of Molecular Sciences 27(13):5744 (2026)

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2. Hyunjung Oh, Hongju Kim, Hojin Kang, Dohyeon Kwon, Leon French, Young Ho Park, Young Chul Youn, Seong Soo An, SangYun Kim, Sungmin Kang

   Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study

   Frontiers in Aging Neuroscience 18:1620991 (2026)

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3. Chanda Simfukwe, Seong Soo A. An, Young Chul Youn, Jeena Kang

   Association of qEEG TAR and TBR During Eyes-Open and Eyes-Closed with Plasma Oligomeric Amyloid-β Levels in an Aging Population

   Journal of Clinical Medicine 14(22):8069 (2025)

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4. Danyeong Kim, KyuHwan Shim, Jinho Kim, Geon Ko, Mario A. Tan, Keun-A Chang, Seong Soo A. An

   Potential anti-amyloid beta oligomerization effects of PD166793 in Alzheimer's disease

   Experimental Neurology 396:115504 (2025)

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5. Niti Sharma, Danyeong Kim, Himadri Sharma, Moon Il Kim, Hyon Lee, Minju Kim, Nayoung Ryoo, Min Ju Kang, Jung‐Min Pyun, Young Ho Park, Jisun Ryu, Hyun Jung Oh, Hyun‐Sik Yang, Hang‐Rai Kim, Geon Ha Kim, Sangwon Han, YoungSoon Yang, Young Chul Youn, Charlotte Elisabeth Teunissen, Henrik Zetterberg, Philip Scheltens, Seong Soo A. An, Young-Bum Kim, Sang-Yun Kim

   Bridging the barrier: insights into blood biomarkers and therapeutic strategies targeting choroid plexus and BBB dysfunction in alzheimer’s disease

   Biomarker Research 13(1):116 (2025)

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6. Niti Sharma, Danyeong Kim, Himadri Sharma, Moon Il Kim, Hyon Lee, Minju Kim, Nayoung Ryoo, Min Ju Kang, Jung‐Min Pyun, Young Ho Park, Jisun Ryu, Hyun Jung Oh, Hyun‐Sik Yang, Hang‐Rai Kim, Geon Ha Kim, Sangwon Han, YoungSoon Yang, Young Chul Youn, Charlotte Elisabeth Teunissen, Henrik Zetterberg, Philip Scheltens, Seong Soo A. An, Young‐Bum Kim, Sang-Yun Kim

   Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review

   Alzheimer s & Dementia 21(7):e70475 (2025)

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7. Angelo Jamerlan, Kyu Hwan Shim, Niti Sharma, Seong Soo A. An

   Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers

   International Journal of Molecular Sciences 26(3):1199 (2025)

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8. Angelo Jamerlan, Kyu Hwan Shim, Niti Sharma, Seong Soo A. An

   Multimer Detection System: A Universal Assay System for Differentiating Aggregated Proteins/Oligomers from Monomers

   (2024)

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9. Angelo Jamerlan, Seong Soo A. An, John Hulme

   Current status of fluid biomarkers for early Alzheimer's disease and FDA regulation implications

   Journal of the Neurological Sciences 467:123325 (2024)

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10. Sumin Jeong, Kyu Hwan Shim, Danyeong Kim, Heewon Bae, Da-Eun Jeong, Min Ju Kang, Seong Soo A. An

    Assessment of acetylcholinesterase activity in CD9-positive exosomes from patients with Parkinson’s disease

    Frontiers in Aging Neuroscience 16:1332455 (2024)

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11. Kyu Hwan Shim, Danyeong Kim, Min Ju Kang, Jung‐Min Pyun, Young Ho Park, Young Chul Youn, Kyung Won Park, Kyoungho Suk, Ho‐Won Lee, Bárbara Fernandes Gomes, Henrik Zetterberg, Seong Soo A. An, SangYun Kim

    Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease

    Alzheimer s & Dementia 20(4):2731–2741 (2024)

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12. Angelo Jamerlan, Kyu Hwan Shim, Young Chul Youn, Charlotte Elisabeth Teunissen, Seong Soo A. An, Philip Scheltens, SangYun Kim

    Increased oligomeric TDP‐43 in the plasma of Korean frontotemporal dementia patients with semantic dementia

    Alzheimer s & Dementia 19(9):4020–4027 (2023)

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13. Seong Soo A. An, John Hulme

    Plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive Alzheimer’s disease

    Neural Regeneration Research 18(11):2391–2392 (2023)

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14. Kyu Hwan Shim, Min Ju Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim

    Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease

    Alzheimer s Research & Therapy 14(1):201 (2022)

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15. Angelo Jamerlan, Seong Soo A. An

    A Microplate-Based Approach to Map Interactions between TDP-43 and α-Synuclein

    Journal of Clinical Medicine 11(3):573 (2022)

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16. Min Ju Kang, Kyu Hwan Shim, Jeewon Suh, Jung‐Min Pyun, Nayoung Ryoo, Young Ho Park, Young Chul Youn, Jae‐Won Jang, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Kyoungho Suk, Ho‐Won Lee, Pan‐Woo Ko, Chan‐Nyoung Lee, Tae Sung Lim, Seong Soo A. An, SangYun Kim

    CSF total tau/α‐synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

    Alzheimer s & Dementia 17(S5) (2021)

    DOI

17. Young Ki Choi, Ji Sun Yu, Yechan Joh, Sungmin Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim

    Presence of endogenous Aβ in plasma of patient with Alzheimer’s disease differentiates Aβ oligomerization tendencies caused by synthetic Aβ

    Alzheimer s & Dementia 17(S5) (2021)

    DOI

18. Rosha Babapour Mofrad, Philip Scheltens, SangYun Kim, Sungmin Kang, Young Chul Youn, Seong Soo A. An, Jori Tomassen, Bart N.M. van Berckel, Pieter Jelle Visser, Wiesje M. van der Flier, Charlotte Elisabeth Teunissen

    Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status

    Alzheimer s Research & Therapy 13(1):133 (2021)

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19. Kyu Hwan Shim, Han Gyeol Go, Heewon Bae, Da-Eun Jeong, Danyeong Kim, Young Chul Youn, SangYun Kim, Seong Soo A. An, Min Ju Kang

    Decreased Exosomal Acetylcholinesterase Activity in the Plasma of Patients With Parkinson’s Disease

    Frontiers in Aging Neuroscience 13:665400 (2021)

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20. Jung‐Min Pyun, Ji Sun Ryu, Ryan Yimeng Lee, KyuHawn Shim, Young Chul Youn, Nayoung Ryoo, Sang‐Won Han, Young Ho Park, Sungmin Kang, Seong Soo A. An, SangYun Kim

    Plasma Amyloid-β Oligomerization Tendency Predicts Amyloid PET Positivity

    Clinical Interventions in Aging Volume 16:749–755 (2021)

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21. Amel Sbartai, Nicole J. Jaffrezic-Renault, Daisy Bougard, Christiane Segarra, Chantal Fournier‐Wirth, Shuhao Kang, Kuntaek Lim, Seong Soo A. An

    Magnetic microparticle-based multimer detection system for the electrochemical detection of prion oligomers in sheep using a recyclable BDD electrode

    Microchemical Journal 164:106089 (2021)

    DOIPDF

22. Rosha Babapour Mofrad, Philip Scheltens, Seong Soo A. An, Sungmin Kang, SangYun Kim, Bart N.M. van Berckel, Pieter Jelle Visser, Wiesje M. van der Flier, Charlotte Elisabeth Teunissen

    Plasma amyloid‐β oligomerization assay as a screening test for abnormal amyloid status

    Alzheimer s & Dementia 16(S4) (2020)

    DOIPDF

23. Kyu Hwan Shim, Seung Chan Kim, Young Chul Youn, Young Hee Sung, Seong Soo A. An

    Decreased plasma α-synuclein in idiopathic Parkinson’s disease patients after adjusting hemolysis factor

    Molecular & Cellular Toxicology 16(4):477–484 (2020)

    DOI

24. Angelo Jamerlan, Seong Soo A. An

    The influence of Aβ-dependent and independent pathways on TDP-43 proteinopathy in Alzheimer’s disease: a possible connection to LATE-NC

    Neurobiology of Aging 95:161–167 (2020)

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25. Angelo Jamerlan, Seong Soo A. An, John Hulme

    Advances in amyloid beta oligomer detection applications in Alzheimer's disease

    TrAC Trends in Analytical Chemistry 129:115919 (2020)

    DOI

26. Young Chul Youn, Byoung Sub Lee, Gwang Je Kim, Ji Sun Ryu, Kuntaek Lim, Ryan Lee, Jeewon Suh, Young Ho Park, Jung‐Min Pyun, Nayoung Ryu, Min Ju Kang, Hye Ryoun Kim, Sungmin Kang, Seong Soo A. An, SangYun Kim

    Blood Amyloid-β Oligomerization as a Biomarker of Alzheimer’s Disease: A Blinded Validation Study

    Journal of Alzheimer s Disease 75(2):493–499 (2020)

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27. Xue Wei Meng, Tao Li, Xiao Wang, Xiaozhen Lv, Zhiyu Sun, Jichun Zhang, Su Feng, Sungmin Kang, SangYun Kim, Seong Soo A. An, Xin Yu, Chen Zhang, Huali Wang

    Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease

    Alzheimer s Research & Therapy 11(1):89 (2019)

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28. Sungmin Kang, Jeewon Suh, Jeong Min Pyun, Young Chul Youn, Ji Sun Yu, Gwang Je Kim, Byoung-sub Lee, Aerim Choe, Yechan Joh, Shinwon Kim, Shinwon Kim, Ryan Lee, Seong Soo A. An, Chang Wan Oh, SangYun Kim, SangYun Kim

    Correlation between oligomerizaton of amyloid beta in plasma and other Alzheimer's disease biomarkers

    IBRO Reports 6:S91 (2019)

    DOIPDF

29. Angelo Jamerlan, Jacqueline C. Dominguez, Antonio D. Ligsay, Young Chul Youn, Seong Soo A. An, SangYun Kim

    Current fluid biomarkers, animal models, and imaging tools for diagnosing chronic traumatic encephalopathy

    Molecular & Cellular Toxicology 15(4):353–368 (2019)

    DOI

30. Seong Soo A. An, Gil Yong Park, Angelo Jamerlan, Kyuhwan Shim

    Transthyretin oligomers as a biomarker for heart failure

    IBRO Reports 6:S302 (2019)

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31. Vo Van Giau, Eva Bagyinszky, Seong Soo A. An

    Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment

    International Journal of Molecular Sciences 20(17):4149 (2019)

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32. KyuHwan Shim, Angelo Jamerlan, Seong Soo A. An

    P2‐060: DRUG SCREENING AGAINST Aβ42 OLIGOMERIZATION

    Alzheimer s & Dementia 15(7S_Part_11) (2019)

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33. Giau Van Vo, Seong Soo A. An

    P4‐029: CHARACTERIZING AFFINITY EPITOPES BETWEEN FIBRINOGEN AND β‐AMYLOID USING AN EPITOPE MAPPING IMMUNOASSAY

    Alzheimer s & Dementia 15(7S_Part_24) (2019)

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34. Young Chul Youn, Sungmin Kang, Jeewon Suh, Young Ho Park, Min Ju Kang, Jung‐Min Pyun, Seong Hye Choi, Jee Hyang Jeong, Kyung Won Park, Ho‐Won Lee, Seong Soo A. An, Jacqueline C. Dominguez, SangYun Kim

    Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease

    Alzheimer s Research & Therapy 11(1):40 (2019)

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35. Vo Van Giau, Seong Soo A. An

    Epitope Mapping Immunoassay Analysis of the Interaction between β-Amyloid and Fibrinogen

    International Journal of Molecular Sciences 20(3):496 (2019)

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36. Seong Soo A. An

    Monitoring amyloid beta oligomers in blood for your brain health

    Journal of Neurological Disorders 06 (2018)

    DOI

37. YoungSoon Yang, Vo Van Giau, Seong Soo A. An, SangYun Kim

    Plasma Oligomeric Beta Amyloid in Alzheimer's Disease with History of Agent Orange Exposure

    Dementia and Neurocognitive Disorders 17(2):41 (2018)

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38. Seong Soo A. An, B.S. Lee, Ji Sun Yu, Kuntaek Lim, G.J. Kim, R. Lee, Seung Ae Kim, S. Kang, Yeon‐Hwan Park, M.J. Wang, YoungSoon Yang, Young Chul Youn, Sang Youn Kim

    Detection of oligomerized amyloid beta in plasma of mild cognitive impairment patient

    Journal of the Neurological Sciences 381:1033 (2017)

    DOI

39. Seong Soo A. An, Byoung Sub Lee, Ji Sun Yu, Kuntaek Lim, Gwang Je Kim, Ryan Lee, Shinwon Kim, Shinwon Kim, Sungmin Kang, Young Ho Park, Young Soon Yang, Young Soon Yang, Young Chul Youn, SangYun Kim, SangYun Kim

    Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42

    Alzheimer s Research & Therapy 9(1):86 (2017)

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40. SangYun Kim, SangYun Kim, Seong Soo A. An, B.S. Lee, Ji Sun Yu, Kuntaek Lim, Gwang Je Kim, Ryan Lee, Shinwon Kim, Shinwon Kim, Sungmin Kang, Young Ho Park, Min Jeong Wang, Young Chul Youn

    [P3–250]: AMYLOID BETA OLIGOMERIZATION IN PLASMA AS A POTENTIAL BLOOD‐BASED BIOMARKER FOR ALZHEIMER's DISEASE

    Alzheimer s & Dementia 13(7S_Part_21) (2017)

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41. Min Cheol Park, Moojong Kim, Gun Taek Lim, Sung Min Kang, Seong Soo A. An, Tae Song Kim, Ji Yoon Kang

    Droplet-based magnetic bead immunoassay using microchannel-connected multiwell plates (μCHAMPs) for the detection of amyloid beta oligomers

    Lab on a Chip 16(12):2245–2253 (2016)

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42. Jisoo Kim, SeJin Kim, Tan Tai Nguyen, Renee Lee, Tiehua Li, Changhyun Yun, Youngeun Ham, Seong Soo A. An, Heongkyu Ju

    Label-Free Quantitative Immunoassay of Fibrinogen in Alzheimer Disease Patient Plasma Using Fiber Optical Surface Plasmon Resonance

    Journal of Electronic Materials 45(5):2354–2360 (2016)

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43. Vo Van Giau, Seong Soo A. An

    Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

    Journal of the Neurological Sciences 360:141–152 (2015)

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44. Seong Soo A. An, Hye Rin Jeong

    Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus

    Clinical Interventions in Aging 10:1873 (2015)

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45. Seong Soo A. An, Tan Tai Nguyen, Sun Oh Bae, Won Jung Yoon, Dong Min Kim, Jin-Won Park, Heongkyu Ju

    A regenerative label-free fiber optic sensor using surface plasmon resonance for clinical diagnosis of fibrinogen

    International Journal of Nanomedicine 10 Spec Iss:155 (2015)

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46. Jae Yeon Joo, Md. Lutful Amin, Thanavel Rajangam, Seong Soo A. An

    Fibrinogen as a promising material for various biomedical applications

    Molecular & Cellular Toxicology 11(1):1–9 (2015)

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47. Ji Yoon Kang, Min Cheol Park, Moojong Kim, Jeong‐Ah Kim, Sung Min Kang, Kuntaek Lim, Seong Soo A. An, Tae Song Kim

    P4‐268: HIGH‐THROUGHPUT SANDWICH ELISA OF AMYLOID BETA OLIGOMERS USING MAGNETIC DROPLET MANIPULATION IN A MODIFIED 96 WELL‐PLATE FOR ALZHEIMER'S DISEASE DIAGNOSIS

    Alzheimer s & Dementia 10(4S_Part_15) (2014)

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48. Seong Soo A. An, Thanavel Rajangam

    Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

    International Journal of Nanomedicine 8:3641 (2013)

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49. Thanavel Rajangam, Seong Soo A. An

    Development of fibrinogen micro carriers as biodegradable scaffolds for skin and vascular engineering

    Journal of Stem Cell Research & Therapy (2013)

50. Seong Soo A. An, Ji Sun Yu, Kuntaek Lim, Byoung Sub Lee, Gwang Je Kim, Sung Min Kang, Young Ho Park, Jae‐Won Jang, Young Chul Yoon, SangYun Kim

    P1–243: The comparison of oligomeric beta‐amyloid and total beta‐amyloid in people with Alzheimer's disease and cognitively normal individuals

    Alzheimer s & Dementia 9(4S_Part_6) (2013)

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51. SangYun Kim, Young Ho Park, Ji Sun Yu, Kuntaek Lim, Byoung Sub Lee, Gwang Je Kim, Sung Min Kang, Young Ho Park, Jae‐Won Jang, Young Chul Yoon, Seong Soo A. An

    P1–245: The effect of anticoagulant and sample preparation method on beta‐amyloid oligomer detection in blood

    Alzheimer s & Dementia 9(4S_Part_6) (2013)

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52. Jae Yeon Joo, MinA Lee, Sunoh Bae, Seong Soo A. An

    Blood biomarkers: from nanotoxicity to neurodegeneration

    SPIE Newsroom (2013)

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53. Kyu Hwan Shim, Min Jeong Jang, Seong Soo A. An, SangYun Kim

    P2‐055: Detection of dissociated autoantibody against beta‐amyloid in CSF and plasma using bridging ELISA

    Alzheimer s & Dementia 8(4S_Part_8) (2012)

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54. Kyu Hwan Shim, Eu Gene Baek, Seung Chan Kime, Hae Ri Na, Young Chul Youn, Seong Soo A. An, SangYun Kim

    P2‐056: Detection of phosphorylated α‐snynuclein monomer and oligomer in blood plasma and cerebrospinal fluid of Parkinson's patients

    Alzheimer s & Dementia 8(4S_Part_8) (2012)

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55. Seong Soo A. An, Kuntaek Lim, Byoung Sub Lee, Gwang Je Kim, Ji Sun Yu, JeongEun Kim, Sung Min Kang, YoungSoon Yang, Young Chul Youn, SangYun Kim

    P4‐252: Blood assay to detect oligomeric beta‐amyloid with high sensitivity and specificity

    Alzheimer s & Dementia 8(4S_Part_20) (2012)

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56. Thanavel Rajangam, Hyun‐jong Paik, Seong Soo A. An

    Development of fibrinogen microspheres as a biodegradable carrier for tissue engineering

    BioChip Journal 5(2):175–183 (2011)

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57. Seong Soo A. An, Kuntaek Lim, Byungsub Lee, Gwang Je Kim, Mino Kang, Seongmin Kang, YoungSoon Yang, Hae Ri Na, Young Chul Youn, SangYun Kim

    P3‐228: Detecting amyloid‐beta oligomers in Alzheimer patient's blood using multimer detection system

    Alzheimer s & Dementia 6(4S_Part_17) (2010)

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58. Sungmin Kang, Kuntaek Lim, Byungsub Lee, Gwang Je Kim, Mino Kang, Younghee Jang, YoungSoon Yang, Hae Ri Na, Young Chul Youn, Seong Soo A. An, SangYun Kim

    P4‐072: Blood Detection of Alzheimer'S Diseases With Multimer Detection System‐ad

    Alzheimer s & Dementia 6(4S_Part_21) (2010)

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59. Seong Soo A. An, Kuntaek Lim, Byungsup Lee, Sungmin Kang, Mino Kang, Young Chul Youn, SangYun Kim

    O1‐06‐06: Diagnosing Ad by Detecting Oligomeric Forms of Beta‐amyloid In Bodily Fluids

    Alzheimer s & Dementia 5(4S_Part_3) (2009)

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60. R Park, Kang‐Il Song, Hyun Joo Doh, Kee Yang Chung, Seong Soo A. An

    A Novel Fibrinogen Variant (Fibrinogen Seoul II : A α Gln328Pro) with Impaired Fibrin α -chain Cross-linking

    16(5):500 (2005)